Related Experiment Video

Updated: May 21, 2026

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
09:11

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

Liver-directed therapies in patients with advanced neuroendocrine tumors

Natalie B Jones1, Manisha H Shah, Mark Bloomston

  • 1Department of Surgery, The Ohio State University, Columbus, OH, USA.

Journal of the National Comprehensive Cancer Network : JNCCN
|June 9, 2012
PubMed

Insights

Neuroendocrine tumors (NETs) are rising, with many diagnosed late with liver metastases. Liver-directed therapies like embolization and ablation offer effective management for advanced NETs when surgery isn't an option.

Area of Science:

  • Oncology
  • Gastroenterology
  • Radiology

Background:

  • Neuroendocrine tumors (NETs) incidence is increasing globally.
  • Many NETs are incidentally discovered due to advanced imaging and screening.
  • Patients often present with advanced, incurable liver metastatic disease, with diagnostic delays averaging 5 years.

Purpose of the Study:

  • To review the latest liver-directed therapeutic approaches for advanced neuroendocrine tumors (NETs).
  • To discuss the role of embolization and ablation in managing NETs with liver involvement.

Main Methods:

  • Review of current literature on liver-directed therapies for advanced NETs.
  • Focus on embolization and ablation techniques.
  • Analysis of symptom control and survival impact.

Main Results:

  • Surgical resection is the only potentially curative option for NETs.
  • Liver-directed therapies provide effective symptom control for advanced NETs.
  • Embolization and ablation can potentially impact overall survival in NET patients.

Conclusions:

  • Advanced imaging and screening increase incidental NET detection.
  • Liver-directed therapies are crucial for managing advanced NETs, especially with liver metastases.
  • Embolization and ablation represent vital alternatives for NET patients ineligible for surgery.

More Related Videos

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...