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A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
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Permanent haemichorea associated with transient hyperglycemia.
Hannah Slabu1, Sheila Savedia-Cayabyab, Peter Senior
1Department of Medicine, University of Alberta, Edmonton, Canada.
BMJ Case Reports
|June 9, 2012
Summary
Chorea, non-ketotic hyperglycemia, and basal ganglia lesions (C-H-BG) is a rare neurological syndrome. This case highlights a Caucasian patient where chorea persisted despite improved glycemic control, challenging the condition's typical benign course.
Area of Science:
- Neurology
- Endocrinology
- Radiology
Background:
- Hyperglycemia is linked to various neurological issues.
- Chorea is a rare neurological syndrome associated with hyperglycemia.
- The Chorea-Hyperglycemia-Basal Ganglia (C-H-BG) syndrome is a recently documented condition.
Observation:
- The C-H-BG syndrome typically presents with chorea, non-ketotic hyperglycemia, and T1-weighted MRI basal ganglia lesions.
- Most reported cases of C-H-BG have occurred in Asian populations.
- This syndrome is generally considered benign, with symptoms resolving upon glucose level normalization.
Findings:
- This report details a case of C-H-BG in a middle-aged Caucasian individual.
- Unlike typical presentations, the chorea in this patient did not resolve with improved glycemic control.
- This suggests potential variations in C-H-BG presentation and prognosis.
Implications:
- The findings challenge the universal benign nature attributed to C-H-BG.
- Further research is needed to understand ethnic variations and prognostic factors in C-H-BG.
- This case underscores the importance of considering persistent neurological symptoms despite metabolic correction.
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