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Related Experiment Video

Updated: May 21, 2026

Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
12:06

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Published on: May 12, 2011

Acquired retrograde transsynaptic degeneration.

Marta Esteves Guedes1, Ana Catarina Almeida, Maria Sara Patricio

  • 1Ophthalmology Department, Hospital Egas Moniz, Lisbon, Portugal. marta.ce.guedes@gmail.com

BMJ Case Reports
|June 9, 2012
PubMed
Summary

Retrograde transsynaptic degeneration, a visual pathway condition, was observed in a human patient following occipital tumor surgery. This study provides the first MRI evidence of associated optic tract atrophy in a human case.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Neuroimaging

Background:

  • Retrograde transsynaptic degeneration (RTD) in the visual pathway is well-documented in monkeys but sparsely in humans.
  • Human data on RTD, particularly post-neurosurgery, is limited, hindering understanding of its clinical manifestations and diagnostic markers.

Observation:

  • A 24-year-old female with a right occipital ependymoma underwent tumor extraction.
  • Post-surgery, the patient developed left homonymous hemianopia and characteristic 'bow-tie' optic disc atrophy.
  • Magnetic Resonance Imaging (MRI) revealed right occipital cortex lobectomy and ipsilateral optic tract atrophy.

Findings:

  • The clinical presentation of left homonymous hemianopia, optic disc atrophy, and optic tract atrophy strongly suggests retrograde transsynaptic degeneration.
  • This case provides the first documented MRI evidence of retrograde transsynaptic degeneration-associated optic tract atrophy in a human patient.

Implications:

  • This finding expands the understanding of RTD in humans, particularly its occurrence after neurosurgical interventions.
  • The study highlights the utility of MRI in visualizing and confirming RTD-associated optic tract atrophy.
  • Further research into RTD mechanisms and clinical impact in humans is warranted.