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Identification and characterization of single nucleotide polymorphisms (SNPs) in Culex theileri (Diptera: Culicidae)

Berna Demirci1, Yoosook Lee, Gregory C Lanzaro

  • 1Hacettepe University, Faculty of Science, Department of Biology, 06800 Beytepe-Ankara, Turkey. demirci_berna@hotmail.com

Journal of Medical Entomology
|June 12, 2012
PubMed

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Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...