Related Experiment Video
Updated: May 21, 2026

Stab-Wound Mouse Model for Studying Hemorrhage and Inflammation in Traumatic Brain Injury
Published on: February 21, 2025
Open-wound treatment for gunshot to the brain
Pepijn van den Munckhof1, Vincent G Geukers, Fonnet E Bleeker
1Neurosurgical Center Amsterdam, Academic Medical Center, Room H2-241, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. p.vandenmunckhof@amc.uva.nl
Insights
A young girl with a brain gunshot wound survived after undergoing decompressive craniectomy and experimental open-wound treatment for elevated intracranial pressure. She achieved a good functional recovery, showcasing a novel treatment approach for severe traumatic brain injury.
Area of Science:
- Pediatric neurosurgery
- Trauma surgery
- Emergency medicine
Background:
- Gunshot wounds to the brain are rare and life-threatening injuries, particularly in young children.
- Elevated intracranial pressure (ICP) is a critical complication that significantly increases mortality and morbidity.
- Standard treatment protocols for pediatric traumatic brain injury (TBI) may require adaptation for complex penetrating injuries.
Observation:
- A 2.5-year-old girl sustained a gunshot wound to the brain.
- The patient presented with uncontrollably elevated intracranial pressure.
- An emergent bilateral decompressive craniectomy was performed to manage the elevated ICP.
Findings:
- The patient underwent an experimental open-wound treatment following the craniectomy.
- The surgical intervention successfully reduced intracranial pressure.
- The patient demonstrated a positive clinical response to the combined treatment approach.
Implications:
- Bilateral decompressive craniectomy can be a life-saving procedure for pediatric TBI with refractory intracranial hypertension.
- Experimental open-wound management may offer a viable option in select cases of severe TBI.
- This case highlights the potential for good functional recovery even after devastating brain injuries with timely and aggressive intervention.
Abstract:
The authors report a case of a gunshot wound to the brain in a 2.5-year-old girl. To treat the uncontrollably elevated intracranial pressure, the patient underwent bilateral decompressive craniectomy and experimental open-wound treatment. She recovered to a good functional level.
Related Concept Videos
Traumatic Brain Injury l: Introduction
Brain Abscess l: Introduction
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...

