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Published on: July 17, 2021
Human genetic variation: new challenges and opportunities for doping control.
Angela J Schneider1, Matthew N Fedoruk, Jim L Rupert
1The International Centre for Olympic Studies, The University of Western Ontario, London, Ontario, Canada.
Journal of Sports Sciences
|June 12, 2012
Summary
Athlete genetics influence anti-doping tests, necessitating personalized approaches. Genotyping in doping control offers benefits for clean athletes but raises privacy concerns.
Area of Science:
- Sports Science
- Genetics
- Anti-Doping
Background:
- Athlete performance variation stems from genetic and environmental interactions.
- Genetics can influence the effectiveness and detection of certain anti-doping measures.
- Anti-doping authorities face challenges due to genotype-dependent responses to prohibited substances.
Purpose of the Study:
- To review the intersection of genetics and anti-doping control.
- To discuss the potential role and ethical implications of genotyping in anti-doping.
- To explore how genetic data can enhance personalized doping control.
Main Methods:
- Review of existing literature on genetics in sports and doping.
- Analysis of the biological passport program's use of intra-individual variability.
- Discussion of potential applications of genetic data in doping control.
Main Results:
- Genetic variations can affect anti-doping test outcomes.
- The biological passport program accounts for individual variability.
- Genotyping could aid in documenting responses to doping agents and identifying athletes/samples.
Conclusions:
- Genetics presents a complex factor in anti-doping efforts.
- Personalized doping control incorporating genetic data is a potential future direction.
- Ethical considerations, particularly privacy, must be addressed alongside technological advancements.
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