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Updated: May 21, 2026
09:03
Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
Tissue factor proangiogenic signaling in cancer progression
Florence Schaffner1, Naho Yokota, Wolfram Ruf
1Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Thrombosis Research
|June 12, 2012
Summary
The hemostatic system, including tissue factor (TF), drives cancer growth and metastasis. TF-dependent signaling promotes primary tumor expansion, while TF-initiated coagulation aids metastatic spread.
Area of Science:
- Oncology
- Hematology
- Molecular Biology
Background:
- Cancer progression involves multiple steps, from benign tumors to metastasis.
- The hemostatic system plays a critical role in this process.
- Key hemostatic factors like tissue factor (TF) are expressed in both tumor and host cells.
Purpose of the Study:
- To review the evidence linking the hemostatic system to cancer progression.
- To elucidate the specific roles of TF, protease-activated receptors (PARs), factor VIIa, and endothelial protein C receptor (EPCR) in tumor growth and metastasis.
Main Methods:
- Literature review of studies investigating the hemostatic system in cancer.
- Analysis of research on TF-dependent signaling in tumor growth.
- Examination of pathways involved in metastatic dissemination initiated by TF and procoagulant tumor cells.
Main Results:
- TF-dependent signaling is identified as a major driver of primary tumor growth.
- TF-initiated coagulation and interactions with host compartments facilitate metastatic spread.
- Components like PARs and EPCR are involved in regulating tumor growth, angiogenesis, and metastasis.
Conclusions:
- The hemostatic system is integral to cancer progression, influencing both primary tumor growth and metastatic dissemination.
- Targeting TF-dependent pathways may offer therapeutic strategies for inhibiting cancer spread.
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