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Published on: September 9, 2012

Current concepts in the management of disseminated intravascular coagulation

Jecko Thachil1, Cheng Hock Toh

  • 1Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, Prescot Road, Liverpool, United Kingdom. jeckothachil@yahoo.co.uk

Thrombosis Research
|June 12, 2012
PubMed

Insights

Disseminated Intravascular Coagulation (DIC) is a complex syndrome requiring careful diagnosis beyond single markers. Treatment focuses on the underlying cause, with blood products for resuscitation and emerging therapies, though management remains challenging.

Area of Science:

  • Hematology
  • Pathophysiology
  • Clinical Medicine

Background:

  • Disseminated Intravascular Coagulation (DIC) is a critical clinicopathological syndrome.
  • It involves widespread intravascular coagulation triggered by an underlying condition.
  • Thrombin plays a central role in the complex pathophysiology of DIC.

Purpose of the Study:

  • To summarize the understanding of Disseminated Intravascular Coagulation (DIC).
  • To highlight diagnostic challenges and therapeutic approaches for DIC.
  • To emphasize the complexity and ongoing challenges in managing DIC.

Main Methods:

  • Review of the pathophysiology of DIC.
  • Analysis of diagnostic considerations for DIC.
  • Evaluation of current and emerging treatment strategies for DIC.

Main Results:

  • The clinical presentation of DIC is variable and dynamic.
  • Laboratory diagnosis of DIC should integrate multiple markers and results.
  • Management of DIC necessitates addressing the primary trigger and using supportive care.

Conclusions:

  • Effective DIC management requires a comprehensive approach, focusing on the underlying cause.
  • Blood products are crucial for resuscitative measures in DIC.
  • Despite advances, managing DIC continues to present significant clinical challenges.

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