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Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis
Published on: November 28, 2015
Polarizing macrophages through reprogramming of glucose metabolism
Julianna Blagih1, Russell G Jones
1Goodman Cancer Research Centre, Department of Physiology, McGill University, Montreal, QC, Canada, H3G 1Y6.
Cell Metabolism
|June 12, 2012
Abstract:
Reprogramming of intracellular metabolism is common in activated immune cells. In this issue of Cell Metabolism, Haschemi et al. (2012) show that the sedoheptulose kinase CARKL is required for metabolic reprogramming in activated macrophages and provide evidence that changes in glucose metabolism and the pentose phosphate pathway (PPP) influences macrophage polarization.
