Related Experiment Video
Updated: May 21, 2026

06:59
Using the BLT Humanized Mouse as a Stem Cell based Gene Therapy Tumor Model
Published on: December 18, 2012
Target practice: modeling tumors with stem cells
1Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 94158, USA.
Cell
|June 12, 2012
Abstract:
A variant neoplastic line of human pluripotent stem cell (hPSC) displays unique tumorigenic properties, including enhanced self-renewal and survival, and aberrant blockade in differentiation. Sachlos et al. adopted a neoplastic hPSC differentiation platform to screen small molecules that selectively induce differentiation of cancer stem cells.

