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Related Experiment Video

Updated: May 21, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Published on: November 16, 2011

Insulin-like growth factor 1 physiology: lessons from mouse models.

Shoshana Yakar¹, Martin L Adamo

¹Department of Basic Science and Craniofacial Biology, David B. Kriser Dental Center, New York University College of Dentistry, New York, NY 10010-4086, USA. sy1007@nyu.edu

Endocrinology and Metabolism Clinics of North America

|June 12, 2012

Summary

Insulin-like growth factor 1 (IGF-1) influences body size, skeletal development, muscle growth, and metabolism. Mouse models reveal its crucial roles throughout life, impacting longevity.

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Last Updated: May 21, 2026

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Area of Science:

Endocrinology
Developmental Biology
Genetics

Background:

Insulin-like growth factor 1 (IGF-1) is a key polypeptide hormone.
IGF-1 expression is tightly regulated.
It plays critical roles in development and adult physiology.

Purpose of the Study:

To review the multifaceted roles of IGF-1.
To highlight findings from mouse models regarding IGF-1 functions.

Main Methods:

Review of existing literature on IGF-1.
Analysis of data from mouse studies investigating IGF-1.
Focus on physiological and developmental impacts.

Main Results:

IGF-1 is crucial for determining body size.
It significantly impacts skeletal acquisition and muscle growth.
IGF-1 also affects carbohydrate metabolism and longevity.

Conclusions:

Mouse models provide valuable insights into IGF-1 functions.
IGF-1 is a pleiotropic factor essential for normal growth, metabolism, and aging.