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Association between appendicectomy in females and subsequent pregnancy rate: a cohort study
Li Wei1, Thomas MacDonald, Sami Shimi
1Medicines Monitoring Unit, Division of Medical Sciences, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland.
Objective:
To study whether subsequent pregnancy rate is reduced after appendicectomy.
Design:
A cohort study was carried out in the General Practice Research Database, a United Kingdom primary care database.
Setting:
University hospital.
Patient(S):
Female patients who underwent appendicectomy between 1986 and 2009 and appropriate comparators were followed until first pregnancy.
Intervention(S):
None.
Main Outcome Measure(S):
The association between appendicectomy and subsequent pregnancy was determined by Cox regression models.
Result(S):
The analyses included 76,426 appendicectomy patients, with 152,852 comparators from the database. There were 30,030 pregnancies (39.3%) in the appendicectomy cohort and 43,321 (28.3%) in the comparator cohort during a mean (SD) follow-up of 10.5 (6.6) years. Adjusted hazard ratios for subsequent birth rates were 1.54 (95% confidence interval, 1.52-1.56).
Conclusion(S):
Appendicectomy was associated with increased subsequent pregnancy rate in this study. This suggests that a history of appendicectomy is not associated with impaired fertility.
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