Related Experiment Video

Updated: May 21, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Published on: September 13, 2018

Regulators of mammalian Hippo pathway in cancer

Angela M Liu1, Kwong-Fai Wong, Xiaoou Jiang

  • 1Department of Pharmacology, National University of Singapore, Singapore.

Biochimica Et Biophysica Acta
|June 12, 2012
PubMed

Insights

The Hippo pathway controls organ size and restrains cancer. Understanding its regulators, like YAP, offers new therapeutic targets for effective cancer drug development.

Area of Science:

  • Cell Biology
  • Oncology
  • Molecular Biology

Background:

  • The Hippo pathway, conserved from Drosophila to mammals, is crucial for organ size control.
  • This pathway plays a significant role in restraining cancer development.
  • Dysregulation of the Hippo pathway is implicated in various solid malignancies.

Purpose of the Study:

  • To discuss newly identified and key regulators of the Hippo pathway.
  • To explore the connection of these regulators with core Hippo components (MST1/2, LATS1/2, SAV1, MOB1) and the downstream effector YAP.
  • To highlight the role of these regulators in cancer development and progression.

Main Methods:

  • Review of recent scientific literature on Hippo pathway regulators.
  • Analysis of molecular mechanisms connecting regulators to core Hippo pathway components.
  • Discussion of pathway crosstalk and extracellular stimuli influencing Hippo signaling.

Main Results:

  • Identification of novel molecules modulating Hippo pathway signaling.
  • Elucidation of connections between regulators and core Hippo pathway components (MST1/2, LATS1/2, SAV1, MOB1) and YAP.
  • Demonstration of the pathway's role in cancer development and progression.

Conclusions:

  • Understanding mammalian Hippo pathway regulation is key for cancer therapy.
  • New insights may enable selection of appropriate oncogenic targets.
  • Effective drug design for cancer treatment can be advanced through this knowledge.

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