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Updated: May 21, 2026
In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice
Published on: February 20, 2020
Leishmania virulence factors: focus on the metalloprotease GP63
Martin Olivier1, Vanessa Diniz Atayde, Amandine Isnard
1Department of Medicine, The Research Institute of the McGill University Health Centre, Faculty of Medicine, McGill University, Montréal, Québec, Canada. martin.olivier@mcgill.ca
Abstract:
Parasites of Leishmania genus have developed elegant strategies permitting them to evade the innate immune response upon their initial interaction with macrophages. Their capacity to dodge the induction of macrophages microbicidal functions was found to correlate with the alteration of several signalling pathways regulating those latter. In this review, the role of the Leishmania GP63 as a critical virulence factor influencing macrophage physiology will be discussed.
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