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Updated: May 21, 2026
Application of the En Bloc Concept Combined with Anatomic Resection in Laparoscopic Hepatectomy
Published on: March 10, 2023
Resection margin in hepatectomy for hepatocellular carcinoma: a systematic review
Yun-Hao Tang1, Tian-Fu Wen, Xi Chen
1Department of Liver and Vascular Surgery, Sichuan University, Chengdu, Sichuan Province, China.
Background/Aims:
To evaluate the influence of the width of resection margin on recurrence and survival for hepatocellular carcinoma.
Methodology:
Randomized controlled trials and non-randomized trials evaluating the influence of the width of resection margin for HCC were identified using a predefined search strategy. A meta-analysis was performed to estimate pooled recurrence and survival rate.
Results:
One randomized controlled trial and four non-randomized trials were identified. The only randomized controlled trial reported that a margin aiming at 2cm could decrease the recurrence rate (p=0.037) and increase the 3-year survival (p=0.02) and 5-year survival rate (p<0.01) compared with a margin aiming at 1cm. Meta-analysis showed that there was no significant difference between the group with resection margin <1cm and the group with resection margin ≥1cm in recurrence rate (p=0.08), 1-year survival (p=0.75), 3-year survival (p=0.53) and 5-year survival rate (p=0.15).
Conclusions:
A resection margin ≥1cm does not provide significant prognostic benefit compared with a resection margin <1cm. There is limited evidence to show that patients with a resection margin aiming at 2cm have better survival outcome than patients with a resection margin aiming at 1cm.
