Gastrointestinal bleeding and blood transfusion in the elderly in Japan

Taketoshi Suehiro1, Yoichi Yakeishi, Fumitaka Sakai

  • 1Department of Surgery, Shin-Nakama Hospital, Nakama, Japan. taketoshisuehiro2004@yahoo.co.jp

Insights

Elderly patients with gastrointestinal bleeding (GIB) often require more blood transfusions, especially if using antithrombotic drugs. This study suggests a restrictive transfusion strategy is feasible for managing GIB across age groups.

Area of Science:

  • Gastroenterology
  • Hematology
  • Geriatrics

Background:

  • Gastrointestinal bleeding (GIB) incidence rises with age.
  • Blood transfusions are common for GIB management.
  • Age-related differences in GIB and transfusion needs require investigation.

Purpose of the Study:

  • To summarize data on patients with GIB.
  • To analyze the relationship between blood transfusion and age in GIB patients.
  • To compare transfusion management in elderly versus younger GIB patients.

Main Methods:

  • Patients with GIB were categorized into two age groups: elderly (≥75 years) and younger (<75 years).
  • Causes and clinical outcomes, including blood transfusions, were compared between groups.
  • Analysis focused on transfusion requirements and pre-transfusion hemoglobin levels.

Main Results:

  • Out of 120 GIB patients, 31% received blood transfusions.
  • Elderly patients, particularly those on antithrombotic drugs, required greater transfusion volumes.
  • Elderly patients without antithrombotics had significantly lower hemoglobin levels than younger counterparts.

Conclusions:

  • The study's blood transfusion strategy appears compatible with a restrictive approach.
  • Findings highlight age-related variations in transfusion needs for GIB.
  • Further research may refine transfusion guidelines for elderly GIB patients.
Abstract

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...