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Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
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Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

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Venous Thrombosis III: Interprofessional Care

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Updated: May 21, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
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Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

Brentuximab vedotin.

Niels W C J van de Donk1, Eugen Dhimolea

  • 1Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA USA. n.w.c.j.vandedonk@umcutrecht.nl

Mabs
|June 12, 2012
PubMed
Summary
This summary is machine-generated.

Brentuximab vedotin targets CD30+ cancers by releasing an anti-cancer agent. While effective in lymphomas, it can cause cumulative nerve damage, prompting ongoing research for new uses and safety improvements.

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Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
04:48

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Published on: January 7, 2015

Area of Science:

  • Oncology
  • Pharmacology
  • Immunotherapy

Background:

  • Brentuximab vedotin is an antibody-drug conjugate targeting CD30.
  • It delivers monomethyl auristatin E (MMAE) to cancer cells, inducing apoptosis.
  • CD30 is a target in certain lymphomas and lymphoproliferative disorders.

Purpose of the Study:

  • To review the efficacy and safety of brentuximab vedotin.
  • To highlight its use in relapsed/refractory Hodgkin lymphoma and anaplastic large cell lymphoma.
  • To discuss ongoing clinical trials in various CD30-positive malignancies.

Main Methods:

  • Review of clinical trial data for brentuximab vedotin.
  • Analysis of safety profiles, focusing on peripheral sensory neuropathy.
  • Examination of ongoing studies in newly diagnosed and relapsed/refractory settings.

Main Results:

  • Durable antitumor activity observed in Hodgkin lymphoma and systemic anaplastic large cell lymphoma.
  • Manageable safety profile, with peripheral sensory neuropathy as a key dose-limiting toxicity.
  • Ongoing trials explore combinations and new indications.

Conclusions:

  • Brentuximab vedotin demonstrates significant efficacy in CD30-positive hematologic malignancies.
  • Peripheral sensory neuropathy requires careful monitoring and management.
  • Further research is warranted to optimize its use and expand its therapeutic applications.