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Related Concept Videos

Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...

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Visualizing the complex brain dynamics of chronic pain.

Carl Saab1

  • 1Department of Neuroscience, Brown University Alpert Medical School, Providence, RI 02903, USA. carl_saab@brown.edu

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on Neuroimmune Pharmacology
|June 12, 2012
PubMed
Summary
This summary is machine-generated.

Chronic pain alters brain structure and function, indicating a disease state. Emerging analytical electroencephalography (EEG) methods offer objective diagnostic tools for managing chronic pain by targeting brain changes.

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Area of Science:

  • Neuroscience
  • Pain Medicine
  • Medical Technology

Background:

  • Chronic pain is increasingly understood as a disease involving brain alterations.
  • Structural and functional brain remapping occurs in chronic pain conditions.
  • Aberrant neurophysiology confirms neuroplasticity at cellular and molecular levels.

Purpose of the Study:

  • To explore the concept of chronic pain as a disease state impacting brain function.
  • To highlight the potential of emerging technologies for diagnosing pain-induced brain changes.
  • To investigate objective diagnostic measures for effective chronic pain management.

Main Methods:

  • Review of data documenting structural and morphological brain remapping in chronic pain.
  • Examination of evidence for aberrant neurophysiology and neuroplasticity.
  • Discussion of analytical electroencephalography (EEG) as a non-invasive diagnostic tool.

Main Results:

  • Chronic pain is associated with significant changes in brain circuitry and function.
  • Neuroplasticity is evident at cellular and molecular levels in chronic pain states.
  • Analytical EEG methods show promise for detecting pain-induced brain alterations.

Conclusions:

  • Chronic pain represents a disease state with demonstrable brain changes.
  • Non-invasive technologies like analytical EEG can provide objective diagnostic measures.
  • Targeting brain interventions guided by objective measures may improve chronic pain management.