Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antibiotic Selection00:57

Antibiotic Selection

Overview
Inhibitors of Bacterial Protein Synthesis01:25

Inhibitors of Bacterial Protein Synthesis

Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
Production of Antibiotics01:27

Production of Antibiotics

Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...
Inhibitors of Gram-positive Cell Wall Synthesis01:23

Inhibitors of Gram-positive Cell Wall Synthesis

Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...
Inhibitors of Bacterial DNA Synthesis01:28

Inhibitors of Bacterial DNA Synthesis

Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These antibiotics are selectively...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Growth of Palate in Unilateral Cleft Lip and Palate Patients Undergoing Two-stage Palatoplasty and Orthodontic Treatment.

The Bulletin of Tokyo Dental College·2018
Same author

Two-year Survey of Trends at Food Introduction Booth at Suidobashi Hospital of Tokyo Dental College.

The Bulletin of Tokyo Dental College·2018
Same author

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase.

Emerging infectious diseases·2018
Same author

[Clinical Characteristics of Adult Onset RSV Infection During Two Consecutive Winter Seasons].

Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases·2018
Same author

The Feature of Solitary Small Nodular Type of Hepatic Epithelioid Hemangioendothelioma.

Case reports in gastroenterology·2018
Same author

Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents.

The New England journal of medicine·2018
Same journal

Quantitative evaluation of pyuria with a hemocytometer in children on clean intermittent catheterization.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2026
Same journal

Device-Associated Infection Surveillance in Japan: 2025 Annual Report of the Japanese Society for Infection Prevention and Control.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2026
Same journal

Letter to the editor: Sex-stratified urinalysis thresholds and pre-analytic comparability in urine culture prediction.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2026
Same journal

Clinical characteristics of Providencia rettgeri bacteraemia and antimicrobial susceptibility patterns.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2026
Same journal

Therapeutic drug monitoring-guided linezolid salvage therapy for Lacticaseibacillus paracasei infective endocarditis: A case report.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2026
Same journal

Comprehensive risk assessment and evaluation of the impact of amino acid preparations on peripheral line-associated bloodstream infection: A single-center retrospective observational study using propensity score matching.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2026
See all related articles

Related Experiment Video

Updated: May 21, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

Generic antibiotics in Japan.

Shigeru Fujimura1, Akira Watanabe

  • 1Research Division for Development of Anti-Infective Agents, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan. fujimo@idac.tohoku.ac.jp

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|June 12, 2012
PubMed
Summary
This summary is machine-generated.

Generic drugs offer cost savings but face low adoption in Japan due to distrust and lower profit margins. Studies reveal some generic antibiotics have reduced potency and solubility compared to branded versions.

More Related Videos

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

Site-specific Bacterial Chromosome Engineering: ΦC31 Integrase Mediated Cassette Exchange (IMCE)
08:21

Site-specific Bacterial Chromosome Engineering: ΦC31 Integrase Mediated Cassette Exchange (IMCE)

Published on: March 16, 2012

Related Experiment Videos

Last Updated: May 21, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
11:56

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

Site-specific Bacterial Chromosome Engineering: ΦC31 Integrase Mediated Cassette Exchange (IMCE)
08:21

Site-specific Bacterial Chromosome Engineering: ΦC31 Integrase Mediated Cassette Exchange (IMCE)

Published on: March 16, 2012

Area of Science:

  • Pharmacoeconomics
  • Pharmaceutical Sciences
  • Infectious Diseases

Background:

  • Generic drug use is limited in Japan despite cost-saving benefits.
  • Low adoption rates are attributed to distrust and lower profit margins.
  • Antibiotics are crucial for acute infections, requiring precise dosing.

Purpose of the Study:

  • To investigate the potency and solubility of generic antibiotics compared to branded counterparts.
  • To address concerns regarding the equivalency of generic antibiotics for effective treatment.
  • To inform future policies aimed at increasing generic drug diffusion in Japan.

Main Methods:

  • Comparative analysis of generic and branded antibiotics.
  • Potency and solubility testing of vancomycin, teicoplanin, and meropenem.
  • Evaluation of drug dissolution times and potential causes for differences.

Main Results:

  • Generic vancomycin and teicoplanin showed 14.6% and 17.3% lower potency, respectively.
  • Generic meropenem injection required significantly longer solubilization time (82s vs. 21s).
  • Differences in particle size and solubilizer amount may explain variations.

Conclusions:

  • Generic antibiotics may exhibit reduced antibacterial potency and solubility.
  • Equivalency in efficacy and safety requires further investigation for widespread adoption.
  • Addressing these quality concerns is crucial for Japan's generic drug policy goals.