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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: May 21, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Genomics screens for metastasis genes.

Jinchun Yan1, Qihong Huang

  • 1University of Washington Medical Center, 1959 N. E. Pacific Street, Seattle, WA 98195, USA. jyan@u.washington.edu

Cancer Metastasis Reviews
|June 12, 2012
PubMed
Summary

Metastasis causes most cancer deaths. This review covers genetic tools and methods to identify genes regulating cancer spread, crucial for developing new treatments.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Metastasis is the primary cause of cancer-related mortality.
  • The metastatic process involves complex, coordinated gene regulation in tumor and host tissues.
  • Understanding these genetic programs is key to targeting metastasis.

Purpose of the Study:

  • To review genetic tools and methods for identifying metastasis-regulating genes.
  • To highlight the importance of genomic and functional genomic analyses in metastasis research.

Main Methods:

  • Review of existing literature on genetic tools and methods.
  • Systematic identification of genes involved in metastasis through genomic approaches.
  • Functional genomic analyses to characterize gene roles in metastasis.

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Experimental Metastasis Assay
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Experimental Metastasis Assay

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Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model

Published on: February 3, 2021

Related Experiment Videos

Last Updated: May 21, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Experimental Metastasis Assay
08:28

Experimental Metastasis Assay

Published on: August 24, 2010

Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model
07:03

Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model

Published on: February 3, 2021

Main Results:

  • Identification of critical genes that regulate metastasis.
  • Characterization of genetic programs underlying the metastatic process.
  • Summary of diverse genetic tools and methodologies.

Conclusions:

  • Genetic approaches are essential for dissecting metastasis.
  • Identifying metastasis genes provides targets for novel therapeutic strategies.
  • Further research using these tools will advance cancer treatment.