Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longevity.

Clinical medicine & research·2026
Same author

Comparing incidence of heart failure in individuals with enlarged cardiac chambers versus diabetes.

American journal of preventive cardiology·2026
Same author

AI-CVD-HF: A heart failure risk prediction model based on coronary artery calcium scans compared with PREVENT-HF.

American journal of preventive cardiology·2026
Same author

Organ-Specific Efficacy of Postischemic Empagliflozin in Acute Stroke and Myocardial Infarction Using Preclinical Models.

Journal of the American Heart Association·2026
Same author

Sex Differences in the Adverse Effects of Nicotine-Free E-Cigarettes on Myocardial Oxygen Supply and Demand Balance: A Preclinical Rat Study.

Journal of the American Heart Association·2026
Same author

AI-Derived LA Volume Index, LA/RA and LA/LV Volume Ratios From Coronary Artery Calcium Scans Predict Long-Term Atrial Fibrillation and Stroke.

Stroke·2026

Related Experiment Video

Updated: May 21, 2026

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound
13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

Treating peripheral arterial disease percutaneously with atherectomy.

Bryan G Schwartz1, Robert A Kloner, Steven Burstein

  • 1Heart Institute, Good Samaritan Hospital, Los Angeles, CA 90017-2395, USA. bschwartz15@hotmail.com

The Journal of Invasive Cardiology
|June 12, 2012
PubMed
Summary

Percutaneous revascularization using multiple devices achieved high limb salvage and patency rates, especially with excisional atherectomy. Smoking cessation is recommended for improved outcomes in peripheral artery disease patients.

More Related Videos

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
10:50

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging

Published on: June 29, 2013

Related Experiment Videos

Last Updated: May 21, 2026

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound
13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
10:50

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging

Published on: June 29, 2013

Area of Science:

  • Vascular Surgery
  • Interventional Cardiology
  • Endovascular Interventions

Background:

  • Peripheral artery disease (PAD) management often involves complex revascularization procedures.
  • Optimizing clinical outcomes in patients undergoing percutaneous revascularization (PR) with multiple devices requires further investigation.

Purpose of the Study:

  • To evaluate the clinical outcomes, including limb salvage and patency rates, of patients undergoing percutaneous revascularization (PR) utilizing multiple devices.
  • To identify predictors of amputation and loss of patency in this patient cohort.

Main Methods:

  • Retrospective review of percutaneous revascularization (PR) cases at a tertiary referral hospital.
  • Kaplan-Meier method for calculating limb salvage and patency rates.
  • Multivariate Cox proportional hazards models to analyze historical and procedural factors.

Main Results:

  • Sixty-six patients (87 limbs) with 261 lesions were analyzed; 38 patients had critical limb ischemia (CLI).
  • High rates of limb salvage (75% at 3 years for CLI) and overall patency (75% at 3 years) were observed.
  • Excisional atherectomy was associated with maintained overall patency (HR, 0.36; P=.01), while higher creatinine, Rutherford category, and history of coronary artery bypass graft (CABG) predicted amputation.

Conclusions:

  • An aggressive percutaneous revascularization (PR) strategy employing multiple devices, particularly atherectomy, yields favorable limb salvage and patency rates.
  • Excisional atherectomy and smoking cessation may be crucial for improving patency in patients with peripheral artery disease (PAD).