Long-term successful percutaneous coronary intervention in factor VII deficiency

Area of Science:

• Cardiology
• Hematology
• Interventional Cardiology

Background:

• Factor VII deficiency (FVIId) is a rare inherited bleeding disorder.
• Percutaneous coronary intervention (PCI) necessitates anticoagulation and antiplatelet therapy.
• Limited data exists on PCI feasibility in FVIId patients.

Observation:

• A 55-year-old male with FVIId underwent successful PCI.
• Periprocedural challenges included anticoagulation management and achieving hemostasis at the arterial puncture site.
• The patient tolerated long-term dual antiplatelet therapy post-PCI.

Findings:

• Successful PCI was achieved in an FVIId patient.
• Appropriate anticoagulation and hemostasis strategies were critical.
• Long-term safety of antiplatelet therapy in this context was demonstrated.

Implications:

• PCI is a viable option for FVIId patients with coronary artery disease.
• Future recombinant FVIId administration may be considered for such patients.
• This case expands treatment possibilities for complex cardiovascular interventions in rare bleeding disorders.