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Spontaneous coronary thrombosis following thrombolytic therapy for acute cardiovascular accident and stroke: a case

Eric L Wallace1, Susan S Smyth

  • 1Division of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky, The Lexington VA Medical Center, 900 S. Limestone Street, 326 CTW Building, Lexington, KY 40536-0200, USA. eric.wallace@uky.edu

Journal of Thrombosis and Thrombolysis
|June 12, 2012
PubMed

Insights

Cardiac complications after stroke are common but often asymptomatic. This case highlights rare spontaneous coronary thrombosis after stroke treatment, suggesting a systemic pro-thrombotic state.

Area of Science:

  • Cardiology
  • Neurology
  • Vascular Medicine

Background:

  • Cardiac complications are frequent sequelae of stroke or acute cerebrovascular accidents (CVA).
  • Many post-stroke cardiac events are subclinical and do not lead to adverse outcomes.
  • Symptomatic cardiac events, like myocardial infarction post-CVA, are rare and often linked to embolic sources, such as left ventricular thrombus.

Observation:

  • This report details a rare case of spontaneous coronary thrombosis.
  • The thrombosis occurred following thrombolytic therapy for an acute CVA.
  • This event was observed in a patient with a potential underlying systemic pro-thrombotic state.

Findings:

  • Spontaneous coronary thrombosis can occur after thrombolytic therapy for CVA.
  • The case suggests a link between CVA treatment and coronary thrombosis.
  • An underlying systemic pro-thrombotic state may increase thrombosis risk in multiple vascular beds.

Implications:

  • Clinicians should consider underlying pro-thrombotic states in patients with CVA.
  • Further research is needed to understand the link between CVA, thrombolytic therapy, and coronary thrombosis.
  • This case underscores the importance of evaluating cardiac health in stroke patients, even after treatment.

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