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Macrolides in chronic inflammatory skin disorders.
Abdullateef A Alzolibani1, Khaled Zedan
1Dermatology Department, College of Medicine, Qassim University, PO Box 30109, Buraidah 51477, Saudi Arabia. azolibani@yahoo.com
Mediators of Inflammation
|June 12, 2012
Summary
Macrolide antibiotics, like erythromycin, show anti-inflammatory effects beyond their antimicrobial properties. Studies explore their potential to treat noninfectious inflammatory skin and hair disorders, acting as disease-modifying agents.
Area of Science:
- Dermatology
- Pharmacology
- Immunology
Background:
- Macrolide antibiotics, notably erythromycin, demonstrated efficacy in altering diffuse panbronchiolitis course.
- Beyond antimicrobial action, macrolides possess significant anti-inflammatory properties.
Purpose of the Study:
- To review clinical studies and case reports on macrolide use in dermatological conditions.
- To assess the therapeutic potential of macrolides in noninfectious inflammatory skin and hair disorders.
Main Methods:
- Literature review of clinical studies.
- Analysis of case reports on macrolide treatment.
- Focus on dermatoses previously classified as noninfectious.
Main Results:
- Macrolides exhibit anti-inflammatory effects applicable to various dermatoses.
- Evidence suggests macrolides may serve as disease-modifying agents in selected skin conditions.
- Potential benefits observed in rosacea, psoriasis, and alopecia areata, among others.
Conclusions:
- Macrolide antibiotics show promise as a treatment modality for specific noninfectious inflammatory dermatoses.
- Further research is warranted to establish macrolides as disease-modifying agents in dermatology.
- The anti-inflammatory properties of macrolides are key to their potential in treating various skin and hair disorders.
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