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Related Experiment Video

Updated: May 21, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

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Relationship between human aging muscle and oxidative system pathway.

Enrico Doria¹, Daniela Buonocore, Angela Focarelli

¹Laboratory of Pharmaco-Biochemistry, Nutrition and Nutraceutical of Wellness, Department of Biology and Biotechnology, University of Pavia 9, 27100 Pavia, Italy. enrico.doria@unipv.it

Oxidative Medicine and Cellular Longevity

|June 12, 2012

Summary

Aging muscle leads to sarcopenia, a decline in function. This is driven by cellular aging, mitochondrial dysfunction, and increased reactive oxygen species (ROS), overwhelming antioxidant defenses.

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Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

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Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells

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Published on: July 22, 2013

Area of Science:

Gerontology
Skeletal Muscle Physiology
Cellular Biology

Background:

Aging is associated with muscle mass and strength decline, termed sarcopenia.
Cellular aging involves mitochondrial dysfunction and increased reactive oxygen species (ROS) production.
An imbalance between ROS production and antioxidant defenses characterizes the aging process.

Purpose of the Study:

To review studies on oxidative stress in aging human skeletal muscles.
To analyze the impact of physiological factors like sex, fiber composition, and muscle type on oxidative stress in aging muscle.

Main Methods:

Literature review of existing studies.
Analysis of data considering physiological variations.

Main Results:

Aging skeletal muscle exhibits increased oxidative stress.
Mitochondrial dysfunction is a key cellular mechanism in muscle aging.
Physiological factors can modulate the effects of oxidative stress on muscle aging.

Conclusions:

Oxidative stress is a significant contributor to muscle aging and sarcopenia.
Understanding these mechanisms is crucial for developing interventions.
Further research should explore sex- and muscle-type-specific responses to oxidative stress.