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Related Experiment Videos

Diabetic ulcers--a clinical and bacteriological study.

McLigeyo1, S Oumah, Otieno

  • 1College of Health Sciences, University of Nairobi, Department of Medicine, Kenya.

West African Journal of Medicine
|April 1, 1990
PubMed
Summary

Diabetic foot ulcers are often gangrenous, affecting big toes, and frequently complicated by osteomyelitis. Amoxicillin-clavulanate and clindamycin showed efficacy in acute diabetic ulcer infections.

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Area of Science:

  • Podiatry
  • Infectious Diseases
  • Endocrinology

Background:

  • Diabetic foot ulcers are a significant complication of diabetes mellitus.
  • Gangrenous ulcers are more prevalent than neuropathic ones in this patient cohort.
  • Osteomyelitis is a common comorbidity in patients with diabetic ulcers.

Purpose of the Study:

  • To characterize the clinical features and microbiological profiles of diabetic ulcers.
  • To evaluate the effectiveness of antimicrobial agents in treating diabetic foot infections.

Main Methods:

  • Prospective study of 100 consecutive diabetic ulcer patients over 8 months.
  • Clinical assessment, microbiological cultures, and treatment response evaluation.
  • Analysis of ulcer type, location, comorbidities, and causative organisms.

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Main Results:

  • 83% of patients had non-insulin dependent diabetes mellitus.
  • 69% of ulcers were gangrenous, frequently involving the big toe.
  • Staphylococcus aureus and Escherichia coli were the most common pathogens; osteomyelitis occurred in 44% of patients.
  • Amoxicillin-clavulanate and clindamycin were effective for ulcers with acute features.

Conclusions:

  • Diabetic foot ulcers, particularly gangrenous types, present a substantial clinical challenge.
  • Effective management requires addressing polymicrobial infections and associated osteomyelitis.
  • Specific antibiotic combinations demonstrate utility in treating acute diabetic ulcer infections.