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Updated: May 21, 2026

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children
Published on: August 19, 2020
Cerebral regional oxygen saturation (crSO2): are different sensors comparable?
Nicholas Morris1, Gerhard Pichler, Mirjam Pocivalnik
1Division of Neonatology, Department of Pediatrics, Medical University of Graz, Graz, Austria.
Background:
For measurement of cerebral regional oxygen saturation (crSO2) in neonates, one of the frequently used near-infrared spectroscopy devices is the INVOS 5100 with either the neonatal or pediatric sensor. Measurements between adult and pediatric sensors use different algorithms and differ by 10%. There are no published data comparing neonatal and pediatric sensors.
Objective:
Aim of this study was to compare the neonatal sensor with the pediatric sensor of the INVOS 5100 device in a mixed cohort of neonates to recognize possible differences and enable interpretation of data.
Methods:
In 40 neonates, crSO2 was measured in identical positions using both the neonatal and the pediatric sensor under identical conditions. Each sensor was reapplied five times to calculate mean values and standard deviations.
Results:
Cerebral regional oxygen saturation measurements using the neonatal sensor (mean, 76.1 ± 7.9) and crSO2 measurements using the pediatric sensor (mean, 76.4 ± 8.1) were not different. Reproducibility was not significantly different with similar means of standard deviations (neonatal, 3.7 ± 1.6; pediatric, 3.1 ± 1.3).
Conclusion:
In a mixed cohort of neonates, crSO2 measurements were identical when using the INVOS 5100 neonatal sensor and the pediatric sensor. We conclude that studies using the INVOS 5100 neonatal or pediatric sensor are well comparable.
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