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Updated: May 21, 2026

Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease
Published on: October 20, 2023
Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances
Wei-Ye Liu1, Zhi-Bin Wang, Li-Chao Zhang
1Department of Pharmacology, Second Military Medical University, Shanghai, China.
Abstract:
Blood-brain barrier (BBB) is a dynamic interference that regulates the nutrition and toxic substance in and out of the central nervous system (CNS), and plays a crucial role in maintaining a stable circumstance of the CNS. Tight junctions among adjacent cells form the basic structure of BBB to limiting paracellular permeability. In the present review, the constituents of tight junction proteins are depicted in detail, together with the regulation of tight junction under stimulation and in pathological conditions. Tight junction modulators are also discussed.
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