Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In Vitro Drug Release Testing: Overview, Development and Validation01:10

In Vitro Drug Release Testing: Overview, Development and Validation

In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
Modified-Release Drug Delivery Systems: Bioavailability01:30

Modified-Release Drug Delivery Systems: Bioavailability

Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...
In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

Modified-Release Drug Delivery Systems: Drug Release Characteristics

Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanistic understanding of LAI suspension intramuscular depot formation: A physicochemical perspective.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

API particle size governs in situ forming implant formation, microstructure evolution and performance.

International journal of pharmaceutics·2026
Same author

Loteprednol etabonate nanostructured lipid carriers for enhanced ocular bioavailability.

Colloids and surfaces. B, Biointerfaces·2026
Same author

Spray freeze drying as a novel strategy to enhance oral delivery of proteins/peptides.

International journal of pharmaceutics·2026
Same author

Impact of macrophages on the dissolution of LAI suspension prodrugs.

International journal of pharmaceutics·2026
Same author

Insights into development of long-acting injectable suspensions.

Journal of controlled release : official journal of the Controlled Release Society·2026

Related Experiment Video

Updated: May 21, 2026

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

Accelerated in-vitro release testing methods for extended-release parenteral dosage forms.

Jie Shen1, Diane J Burgess

  • 1Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA.

The Journal of Pharmacy and Pharmacology
|June 13, 2012
PubMed
Summary

Accelerated in-vitro drug release testing methods are crucial for quality control of long-acting injectable drug products. These methods provide rapid evaluation of extended-release parenteral dosage forms, aiding in product development and quality assurance.

More Related Videos

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Related Experiment Videos

Last Updated: May 21, 2026

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Analytical Chemistry

Background:

  • Extended-release parenteral dosage forms are designed for prolonged drug delivery over weeks to years.
  • Traditional 'real-time' in-vitro release testing is time-consuming for these long-acting formulations.
  • Rapid evaluation is essential for quality control and product development.

Purpose of the Study:

  • To review current methods and strategies for accelerated in-vitro drug release testing.
  • To discuss the application of these methods to various extended-release parenteral dosage forms.
  • To highlight the importance of accelerated testing for quality control.

Main Methods:

  • Review of existing literature on accelerated in-vitro release testing methodologies.
  • Discussion of different mechanisms for accelerating drug release.
  • Examination of methods utilizing United States Pharmacopeia (USP) apparatus.

Main Results:

  • Various accelerated in-vitro release methods have been developed using USP apparatus.
  • These methods aim to provide rapid evaluation of drug release profiles.
  • The mechanisms for accelerating drug release from parenteral formulations are explored.

Conclusions:

  • Accelerated in-vitro release testing is critical for ensuring the quality of extended-release parenteral products.
  • Methods with good discriminatory ability are essential for effective quality control.
  • Development of in-vitro-in-vivo correlation (IVIVC) is desirable but may be challenging for complex parenteral products.