[Effects of the decrease of hydrodynamic resistance of a solution on response of cerebral arteries in perfusion]

Acute experiments on isolated segments of carotid arteries of cats and on human middle cerebral arteries have demonstrated the narrowing effect (15-18%) during the perfusion with solution of polymer with extraordinary lengthy (WSR-301, USA) in concentration of 2.10(-6) g/ml. Effects were doze- and endothelial dependent. It has been established that arteries responded to minor changes in experiments with the increase of the fluid flow (from 15 to 40 ml/min). It may be concluded that the diminishing of arteries reaction in the presence of polymer solution depended on the drug reduction polymer influence on shear stress, and changing of angio-hemo relationships.