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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: May 21, 2026

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique
07:34

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique

Published on: December 15, 2023

Stem cell-based therapy for experimental stroke: a systematic review and meta-analysis.

Jennifer S Lees1, Emily S Sena, Kieren J Egan

  • 1Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK.

International Journal of Stroke : Official Journal of the International Stroke Society
|June 13, 2012
PubMed
Summary

This systematic review found that while stem cell therapy shows some benefit in animal stroke models, poor study quality and publication bias may inflate efficacy. Clinical translation requires addressing these data limitations.

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Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
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Published on: June 26, 2020

Related Experiment Videos

Last Updated: May 21, 2026

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique
07:34

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique

Published on: December 15, 2023

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Biomedical Engineering

Background:

  • Stem cell therapy offers potential for treating stroke.
  • Clinical development necessitates robust experimental data.
  • Animal models are crucial for evaluating preclinical efficacy.

Purpose of the Study:

  • To systematically review evidence on stem cell therapy efficacy in animal stroke models.
  • To identify factors influencing treatment outcomes.
  • To inform clinical trial design and stem cell therapy development.

Main Methods:

  • Systematic literature search for stem cell studies in cerebral ischemia animal models.
  • Random effects meta-analysis (DerSimonian and Laird).
  • Assessment of study quality, publication bias, and impact of study characteristics.

Main Results:

  • 117 studies (2332-2704 animals) met inclusion criteria.
  • Poor study quality (median score 4) and publication bias were prevalent.
  • Autologous cells showed higher structural efficacy; allogeneic cells showed higher functional efficacy.
  • Delayed treatment reduced structural efficacy; functional outcome was time-independent.

Conclusions:

  • Stem cell therapy demonstrates some benefit in animal stroke models.
  • Study quality and publication bias potentially confound results.
  • Clinical translation must consider these limitations in preclinical data.