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Bone histomorphometric reference values in 88 normal Italian subjects.

P Ballanti1, E Bonucci, C Della Rocca

  • 1Department of Human biopathology, La Sapienza University of Rome, Italy.

Bone and Mineral
|November 1, 1990
PubMed
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Bone histomorphometry in Italians reveals bone volume (BV/TV) decreases with age in both sexes. Other bone remodeling indicators remain independent of age and sex, suggesting stable bone apposition and resorption processes.

Area of Science:

  • Orthopedics
  • Gerontology
  • Anatomy

Background:

  • Establishing population-specific reference ranges for bone histomorphometry is crucial for accurate diagnosis and treatment.
  • Aging affects bone structure and metabolism, necessitating age- and sex-specific data.

Purpose of the Study:

  • To determine normal bone histomorphometric values in an Italian population.
  • To investigate the influence of age and sex on bone histomorphometric parameters.

Main Methods:

  • Autopsy-derived iliac crest bone specimens from 88 healthy Italian subjects (20-89 years).
  • Measurement of bone volume (BV/TV), osteoid volume, osteoid surface, osteoblast surface, eroded surface, osteoclast surface, and osteoid thickness.
  • Multiple regression analysis to assess age and sex effects, including quadratic and interaction terms.

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Main Results:

  • Bone volume (BV/TV) significantly decreased with age in both males and females, showing a regular pattern.
  • No significant age- or sex-dependent variations were observed for osteoid volume, osteoid surface, osteoblast surface, eroded surface, osteoclast surface, or osteoid thickness.
  • The observed histomorphometric values for the Italian population align with those reported for other Caucasian populations.

Conclusions:

  • Age is a primary determinant of bone volume reduction in healthy Italians.
  • Bone remodeling processes, as indicated by other histomorphometric parameters, appear stable across age and sex in this population.
  • These findings provide valuable reference data for trabecular bone in Italians and support the generalizability of Caucasian bone histomorphometry data.