Nasal carriage of Streptococcus pneumoniae serotypes and Staphylococcus aureus in Streptococcus pneumoniae-vaccinated

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Experimental Human Pneumococcal Carriage
07:47

Experimental Human Pneumococcal Carriage

Published on: February 15, 2013

N H T M Dukers-Muijrers1, E Stobberingh2, P Beisser2

  • 1Department of Sexual Health, Infectious Diseases and Environmental Health, South Limburg Public Health Service, Geleen, The Netherlands.

Epidemiology and Infection
|June 13, 2012
PubMed

Insights

Streptococcus pneumoniae (SPn) conjugate vaccination (PCV) increased non-vaccine type SPn carriage. Staphylococcus aureus (SA) carriage was inversely associated with vaccine-type SPn carriage, particularly with SPn serotype 19A.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Vaccinology

Background:

  • Streptococcus pneumoniae (SPn) conjugate vaccination (PCV) has shifted invasive pneumococcal disease (IPD) to non-vaccine types.
  • An increased burden of Staphylococcus aureus (SA) following PCV implementation has been suggested.

Purpose of the Study:

  • To assess the epidemiology of SA and SPn nasal carriage in children attending day-care centers.
  • To investigate the association between PCV dosage and SPn/SA carriage.

Main Methods:

  • Cross-sectional study of 620 children at day-care centers.
  • Analysis of SPn and SA nasal carriage, with 141 children having received 1-4 doses of PCV7.

Main Results:

  • Higher PCV7 dosage correlated with non-vaccine type SPn carriage.
  • SA carriage was inversely associated with vaccine-type SPn carriage.
  • SPn serotype 19A exhibited higher SA co-carriage rates.

Conclusions:

  • PCV7 implementation did not prevent children from participating in SPn transmission chains.
  • Findings inform monitoring of SA and SPn diseases and the vaccination policy debate regarding PCV7 to PCV10 transition.

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