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The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity

Sang Hui Chu1, Ji-Hye Park, Mi Kyung Lee

  • 1Department of Clinical Nursing Science, Yonsei University College of Nursing, Nursing policy and Research Institute, Biobehavioral Research Center, Seoul, Korea.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|June 13, 2012
PubMed

Insights

Pentraxin-3 (PTX3) levels are linked to lower insulin resistance in obese children. Increased PTX3 after physical activity correlates with improved insulin sensitivity, suggesting PTX3’s role in metabolic health.

Area of Science:

  • Biochemistry and Metabolism
  • Pediatric Endocrinology

Background:

  • The role of pentraxin-3 (PTX3) in insulin resistance development remains unclear.
  • Investigating PTX3's association with insulin resistance and its modulation by physical activity is crucial for understanding pediatric metabolic health.

Purpose of the Study:

  • To determine if circulating PTX3 levels correlate with insulin resistance in overweight/obese children.
  • To assess if changes in PTX3 levels following physical activity are associated with improvements in insulin resistance.

Main Methods:

  • Fifty-seven overweight or obese children (mean age 12.04 years) participated in a controlled study.
  • Physical activity and caloric intake were standardized, with baseline measurements of PTX3 and insulin resistance markers.
  • Changes in PTX3 and insulin resistance were analyzed post-intervention.

Main Results:

  • Baseline PTX3 levels showed a negative correlation with fasting insulin and HOMA-IR, independent of BMI and Tanner stage.
  • Changes in PTX3 levels after physical activity were significantly associated with changes in fasting insulin and HOMA-IR.
  • Children with increased PTX3 levels exhibited greater HOMA-IR improvement compared to those with decreased levels.

Conclusions:

  • Pentraxin-3 (PTX3) is negatively associated with insulin resistance in overweight and obese children.
  • PTX3 levels are dynamically associated with insulin resistance changes induced by physical activity, highlighting its potential role in metabolic regulation.
Abstract

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