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IgG4-related tubulointerstitial nephritis and lymphadenopathy after therapy for malignant lymphoma

Yasuko Oshima1, Ryosuke Usui, Shun Manabe

  • 1Department of Medicine, Division of Nephrology, Yokohama Rosai Hospital, Japan.

Internal Medicine (Tokyo, Japan)
|June 13, 2012
PubMed

We report a middle-aged Japanese man who had a past history of malignant lymphoma with tubulointerstitial nephritis (TIN) presenting a high serum immunoglobulin G4 (IgG4) concentration and bilateral kidney enlargement and swelling of many lymph nodes. Although lymph node biopsy was not evident of a recurrence of lymphoma, kidney biopsy showed prominent infiltration of IgG4-positive plasma cells in a tubulointerstitial lesion but not in glomeruli. We made a diagnosis of IgG4-related TIN and lymphadenopathy; administration of oral prednisolone improved his physical and laboratory parameters. This is the first report of a case of IgG4-related TIN and lymphadenopathy after therapy for malignant lymphoma.

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