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A case of acute kidney injury with marked hyperuricemia during mizoribine administration

Tomoya Nishino1, Takeaki Shinzato, Yuuki Ohta

  • 1Second Department of Internal Medicine, Nagasaki University of Medicine, Japan.

Internal Medicine (Tokyo, Japan)
|June 13, 2012
PubMed

Insights

Mizoribine (MZ) can cause acute kidney injury due to hyperuricemia. This risk highlights the need for caution when prescribing MZ, especially in patients with pre-existing conditions.

Area of Science:

  • Rheumatology
  • Nephrology
  • Clinical Pharmacology

Background:

  • A 52-year-old woman with Blau syndrome and rheumatoid arthritis was treated with prednisolone and methotrexate.
  • Poor control of joint pain and skin ulcers led to the addition of mizoribine (MZ).

Observation:

  • The patient developed acute kidney injury (AKI) and acute pancreatitis after initiating MZ treatment.
  • Elevated serum uric acid (31.6 mg/dL) and MZ levels (5.14 µg/mL) were noted on admission.

Findings:

  • Hyperuricemia during MZ administration was identified as the likely cause of AKI.
  • Markedly elevated uric acid and MZ levels correlated with the patient's adverse events.

Implications:

  • Mizoribine (MZ) administration requires caution due to the risk of severe hyperuricemia.
  • Hyperuricemia-induced AKI is a potential complication of MZ therapy that necessitates careful patient monitoring.

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