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Updated: May 21, 2026

Potentiodynamic Corrosion Testing
Published on: September 4, 2016
Cobalt from metal-on-metal hip replacements may be the clinically relevant active agent responsible for
Alister J Hart1, Paul D Quinn, Ferdinand Lali
1Department of Orthopaedic Surgery, Imperial College and Imperial College Healthcare NHS Trust, Charing Cross Hospital Campus, London, UK. a.hart@ucl.ac.uk
Abstract:
Some types of metal-on-metal (MOM) hip replacements have unacceptably high rates of failure, such as the Ultima TPS MOM hip, with 13.8% failure at 5 years. This has been attributed to an inflammatory reaction following the release of cobalt (Co) and chromium (Cr) from the bearing surfaces and modular junctions. There is in vitro evidence that Co is more important than Cr in the inflammatory process, but there are no reported human tissue studies of the analysis of implant-derived metals.
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