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Related Experiment Video

Updated: May 21, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Hollow microneedle-based sensor for multiplexed transdermal electrochemical sensing.

Philip R Miller1, Shelby A Skoog, Thayne L Edwards

  • 1Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, USA.

Journal of Visualized Experiments : Jove
|June 13, 2012
PubMed
Summary

This study introduces a minimally invasive microneedle sensor for rapid, simultaneous analysis of multiple biological molecules. This technology aids chronic disease management and complex medical research by enabling easy physiological state assessment.

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Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Published on: January 30, 2026

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Biosensors

Background:

  • Chronic medical conditions require continuous monitoring of physiological states.
  • Existing monitoring methods can be invasive or lack speed and selectivity.
  • Microneedle technology, initially for drug delivery, offers access to interstitial fluid.

Purpose of the Study:

  • To develop a minimally invasive, multiplexed monitoring system for rapid analysis of biologically-relevant molecules.
  • To enable facile assessment of physiological states for chronic disease management.
  • To provide a research tool for analyzing complex medical conditions.

Main Methods:

  • Integration of microneedles with microelectrodes for transdermal electrochemical sensing.
  • Utilizing various transducing elements like carbon fibers and modified carbon pastes.
  • Demonstrating selective detection of multiple analytes including glucose, lactate, and hydrogen peroxide.

Main Results:

  • Successful demonstration of selective, simultaneous detection of multiple analytes using microneedle-electrode devices.
  • Microneedle sensors provide a novel approach for in situ monitoring of complex microenvironments.
  • The technology enables rapid and minimally invasive analysis of interstitial fluid.

Conclusions:

  • Microneedle-based multiplexed sensors offer a sophisticated analytical approach for real-time health monitoring.
  • This technology can be applied to monitor key metabolic indicators like glucose, lactate, and pH.
  • It holds potential for improved disease state assessment (e.g., cancer, acidosis) and research applications.