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Related Concept Videos

Karyotyping01:17

Karyotyping

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Karyotyping01:17

Karyotyping

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Lampbrush Chromosomes01:51

Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...
Polytene Chromosomes02:04

Polytene Chromosomes

Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also regularly...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Pedigree Analysis01:35

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Updated: May 21, 2026

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
07:54

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH

Published on: August 19, 2014

Chromosome analyses in dogs.

N Reimann-Berg1, J Bullerdiek, H Murua Escobar

  • 1Stiftung Tierärztliche Hochschule Hannover, Klinik für Kleintiere, Bünteweg 9, 30559 Hannover, Germany.

Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
|June 13, 2012
PubMed
Summary
This summary is machine-generated.

Cytogenetic analysis of canine tumors reveals clonal chromosome aberrations, similar to human cancers. These aberrations can serve as valuable diagnostic and prognostic markers in veterinary medicine.

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Chromosome Preparation From Cultured Cells
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Chromosome Preparation From Cultured Cells

Published on: January 28, 2014

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Last Updated: May 21, 2026

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
07:54

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH

Published on: August 19, 2014

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
06:25

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay

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Chromosome Preparation From Cultured Cells
07:42

Chromosome Preparation From Cultured Cells

Published on: January 28, 2014

Area of Science:

  • Cytogenetics
  • Veterinary Genetics
  • Comparative Oncology

Background:

  • Cytogenetics studies normal and abnormal chromosomes, crucial for understanding species-specific karyotypes.
  • Canine cytogenetics is valuable for breeders, veterinarians, and owners, particularly given shared genetic diseases with humans.
  • The dog serves as a significant model for genetic diseases due to shared conditions like cancer.

Purpose of the Study:

  • To highlight the importance and challenges of cytogenetic investigations in dogs.
  • To compare cytogenetic findings in canine tumors with those in human tumors.
  • To emphasize the role of clonal chromosome aberrations as potential diagnostic and prognostic markers in canine cancer.

Main Methods:

  • Standard cytogenetic techniques for chromosome preparation, similar to human cytogenetics.
  • Analysis of constitutional karyotypes and acquired, tumor-associated chromosome aberrations.
  • Integration of modern molecular genetic approaches and computational tools with conventional cytogenetics.

Main Results:

  • Canine cytogenetic analyses are complicated by a complex karyotype, with a standard classification scheme established only recently.
  • Cytogenetic changes in non-neoplastic canine cells are infrequently reported, mainly involving sex chromosomes.
  • Canine tumors frequently exhibit clonal chromosome aberrations, mirroring findings in human tumors.

Conclusions:

  • Cytogenetic analyses are essential for understanding canine genetic diseases and tumors.
  • Clonal chromosome aberrations in canine tumors hold potential as diagnostic and prognostic markers.
  • While modern techniques enhance cytogenetics, conventional methods remain indispensable for canine cell analysis.