Related Experiment Video
Updated: May 21, 2026
Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Minimally-invasive video-assisted coronary-artery bypass grafting
Rodrigo Mussi Milani1, Paulo Brofman, Maximiliano Guimarães
1Pontifícia Universidade Católica do Paraná, PR- Brazil. grmilani@cardiol.br
Background:
In general, surgeries currently tend to be less invasive and cardiac surgery has started to follow this trend.
Objective:
To evaluate the evolution of one hundred patients undergoing minimally-invasive coronary artery bypass grafting.
Methods:
Access to the heart was attained through a small; 6-cm thoracotomy, located in the 4th left intercostal space, starting at the nipple. Through the same intercostal space, 3 cm after the primary incision, a 6.5-mm optical device was inserted at 30º. Where the saphenous vein was used, the pericardium was opened above the aorta and the latter was partially clamped with a systolic pressure of 80 mmHg, with the proximal anastomosis being carried out in the conventional manner. The distal anastomoses were carried out in the conventional manner. The procedure was performed off-pump using single lung ventilation.
Results:
The mean age was 63.9 ± 10.66 years. Sixty-eight (68%) patients were males. Fifty-three (53%) were in functional class III or IV. Left ventricular function was normal in fifty-three (53%) patients. Forty-two (42%) had undergone previous angioplasty. A total of 153 anastomoses were performed, ranging from 1 to 3. The average ventilation time was 4.06 ± 4.08 hours. Seventeen (17%) patients had atrial fibrillation and eight (8%) had pneumonia. There were two deaths in this series.
Conclusion:
Revascularization was safe with low mortality and morbidity. With the advent of new devices, this surgery may have a greater applicability.
