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Related Experiment Video

Updated: May 21, 2026

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
09:43

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair

Published on: February 24, 2016

Single-stage reconstruction for soft tissue defects: a case series.

Allen Gabriel1, Wendy Wong, Subhas Gupta

  • 1Southwest Medical Group, Department of Surgery, Vancouver, WA, USA. gabrielallen@yahoo.com

Ostomy/Wound Management
|June 13, 2012
PubMed
Summary

This study shows that a single-stage reconstruction using a dermal regeneration template (DRT) and split-thickness skin graft (STSG) with negative pressure wound therapy (NPWT) effectively treats soft tissue defects, avoiding a second surgery.

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Area of Science:

  • Regenerative Medicine
  • Plastic Surgery
  • Wound Healing

Background:

  • Soft tissue defects require effective reconstruction techniques.
  • Two-stage approaches using dermal regeneration templates (DRT) offer improved aesthetics but necessitate repeat surgeries.
  • Split-thickness skin grafts (STSG) can lead to scarring and donor site morbidity.

Purpose of the Study:

  • To evaluate the outcomes of a single-stage reconstruction for complicated soft tissue defects.
  • To assess the efficacy of combining DRT, STSG, and negative pressure wound therapy (NPWT).
  • To determine if a single-stage procedure can avoid the need for a second-stage reconstruction.

Main Methods:

  • A prospective evaluation of 20 patients with soft tissue defects (<200 cm2) following trauma or tumor resection.

Related Experiment Videos

Last Updated: May 21, 2026

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
09:43

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair

Published on: February 24, 2016

  • Single-stage reconstruction involved surgical debridement, DRT application, meshed STSG, and NPWT for 5 days.
  • Patients were followed for 5-19 months post-procedure.

    • Main Results:

    • An average graft take of 98.3% was achieved with an average take time of 5.6 days.
    • No significant differences in graft take were observed based on patient demographics or comorbidities.
    • No wound breakdown, adverse events, or re-operations occurred during the follow-up period.

    Conclusions:

    • Single-stage reconstruction using DRT, STSG, and NPWT is a viable option for soft tissue defects.
    • This approach successfully avoided the need for a second-stage reconstruction surgery.
    • Further randomized controlled trials are warranted to compare different surgical and wound care strategies.