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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
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Development of Immunocompetence01:22

Development of Immunocompetence

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Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

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Related Experiment Video

Updated: May 21, 2026

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Maternal autoantibodies in autism.

Daniel Braunschweig1, Judy Van de Water

  • 1Department of Psychiatry, Davis School of Medicine, Sacramento, CA, USA.

Archives of Neurology
|June 13, 2012
PubMed
Summary

Maternal immune system responses, including fetal brain-reactive antibodies and gestational infections, may influence autism spectrum disorder (ASD) development. Further research is needed to understand these in utero immune exposures and their role in ASD etiology.

Area of Science:

  • Neuroimmunology
  • Developmental Neuroscience
  • Autism Spectrum Disorder (ASD) Research

Background:

  • Rising global rates of autism spectrum disorder (ASD) diagnoses highlight the need for identifying causative factors.
  • Emerging evidence suggests immune system abnormalities, including maternal autoantibodies and gestational immune dysregulation, are associated with ASD.
  • Specific focus on maternal fetal brain-reactive IgG antibodies in mothers of children with autism.

Purpose of the Study:

  • To review current literature on the role of maternal immune system factors in autism spectrum disorder (ASD) etiology.
  • To explore the hypothesis that in utero immune exposures, such as maternal autoantibodies, may influence or cause ASD.
  • To propose future research directions for understanding immune-related contributions to ASD.

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Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
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Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

Related Experiment Videos

Last Updated: May 21, 2026

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
10:16

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

Main Methods:

  • Literature review of published studies investigating maternal immune system parameters and their association with autism spectrum disorder (ASD).
  • Analysis of research on fetal protein reactive IgG antibodies in maternal plasma.
  • Examination of studies on gestational immune parameters like maternal infection and cytokine signaling in relation to ASD.

Main Results:

  • Several studies report increased prevalence of immune system abnormalities in individuals with ASD.
  • Identification of fetal protein reactive IgG antibodies in plasma from mothers of children with autism.
  • Association found between certain gestational immune parameters (maternal infection, cytokine dysregulation) and ASD in some cases.

Conclusions:

  • The hypothesis that maternal autoantibodies or other in utero immune exposures contribute to ASD pathogenesis is an active area of investigation.
  • While mechanisms are not fully determined, maternal immune factors represent a potential influence on ASD development.
  • Further research is crucial to elucidate the precise role of these immune-related exposures in ASD etiology and to develop targeted strategies.