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Updated: May 21, 2026

BRET-based G Protein Biosensors for Measuring G Protein-Coupled Receptor Activity in Live Cells
Published on: November 7, 2025
Chemical probes for the recognition of cannabinoid receptors in native systems
Lidia Martín-Couce1, Mar Martín-Fontecha, Oscar Palomares
1Department of Organic Chemistry, Universidad Complutense de Madrid, Spain.
Abstract:
Receptors made visible: The described biotin-tagged small-molecule probes with excellent affinities for the CB(1) and CB(2) cannabinoid receptors (CB(1)R and CB(2)R) enable direct visualization of these receptors in native cellular systems, including neurons, microglia, and immune cells. This method could overcome some of the limitations of current methodologies and may help to dissect the complexity of the endogenous cannabinoid system.
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