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Multiple organ failure.

P M Dorinsky1, J E Gadek

  • 1Department of Medicine, Ohio State University, Columbus.

Clinics in Chest Medicine
|December 1, 1990
PubMed
Summary
This summary is machine-generated.

Diagnosing organ failure is imprecise, impacting patient survival. Acute respiratory distress syndrome (ARDS) research suggests respiratory failure involves systemic and pulmonary gas exchange abnormalities.

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Area of Science:

  • Critical Care Medicine
  • Pulmonary Medicine
  • Pathophysiology

Background:

  • Diagnostic criteria for organ system failure lack precision, creating ambiguity in clinical research.
  • Multiple organ failure is a frequent complication of Acute Respiratory Distress Syndrome (ARDS) and severe medical/surgical conditions, impacting patient survival.
  • Existing evidence suggests a need to broaden the understanding of acute respiratory failure.

Purpose of the Study:

  • To address the ambiguity in diagnosing organ system failure.
  • To propose a revised conceptualization of acute respiratory failure.
  • To integrate systemic and pulmonary gas exchange abnormalities into the definition of ARDS.

Main Methods:

  • Review of existing investigative evidence on organ system failure and ARDS.

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  • Analysis of gas exchange abnormalities in both pulmonary and systemic microvasculature.
  • Conceptual re-evaluation of the term ARDS.

    • Main Results:

    • Diagnostic imprecision contributes significantly to ambiguity in organ system failure research.
    • Acute respiratory failure, particularly in the context of ARDS, involves abnormal gas exchange in the systemic and pulmonary microvasculature.
    • The term ARDS remains relevant, encompassing respiratory distress in non-pulmonary organs.

    Conclusions:

    • A comprehensive understanding of acute respiratory failure must include systemic gas exchange.
    • The concept of ARDS should encompass broader physiological derangements beyond the lungs.
    • Refining diagnostic criteria is crucial for advancing research in critical care and improving patient outcomes.