[Gallbladder bile proteins in patients with gallstones and normal controls]

The concentration of total protein and 17 different proteins in gallbladder bile of patients with gallstones and normal controls were analyzed. The result showed that the amount of total protein and 11 of 17 proteins was much higher in patients with cholesterol gallstones than that of normal controls. These proteins may be involved in the nucleation of cholesterol crystal in gallbladder bile of patients with cholesterol gallstones. The nucleation activity titre (NAT) of gallbladder bile of patients with gallstones and controls was determined. The NAT of gallbladder bile of patients with gallstones was 1/25-1/100 and that of controls was 1/100-1/6400. There was a statistically significant difference of NAT between patients with cholesterol gallstones and normal controls.