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Related Concept Videos

Decision Making: P-value Method01:09

Decision Making: P-value Method

The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim  is also stated. These statements can act as null and alternative hypotheses:  a null hypothesis would be a neutral statement while the alternative hypothesis can have a...
Time and frequency -Domain Interpretation of PI Control01:27

Time and frequency -Domain Interpretation of PI Control

Proportional-Integral (PI) controllers are essential in many control systems to improve stability and performance. They are commonly used in everyday devices like thermostats to enhance system damping and reduce steady-state error. When the zero in the controller's transfer function is optimally placed, the system benefits significantly in terms of stability and accuracy.
Acting as a low-pass filter, the PI controller slows the system's response and extends settling times. This requires careful...
PI Controller: Design01:24

PI Controller: Design

Proportional Integral (PI) controllers are a fundamental component in modern control systems, widely used to enhance performance and mitigate steady-state errors. They are particularly effective in applications such as automatic brightness adjustment on smartphones, where they excel at mitigating steady-state errors for step-function inputs. Unlike PD controllers, which require time-varying errors to function optimally, PI controllers leverage their integral component to address residual...
Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...

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Sleep Disordered Breathing and Recurrent Tonsillitis Are Associated With Polymicrobial Bacterial Biofilm Infections Suggesting a Role for Anti-Biofilm Therapies.

Frontiers in cellular and infection microbiology·2022
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Related Experiment Video

Updated: May 21, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
09:39

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

Maximising value from PFI contracts.

Karen Prosser1, Russell Gates

  • 1EC Harris, UK.

Health Estate
|June 14, 2012
PubMed
Summary

NHS Trusts can optimize spending on existing healthcare projects by conducting thorough contract savings reviews. This guidance helps trusts identify key elements for maximizing value from Private Finance Initiative (PFI) contracts.

Area of Science:

  • Healthcare Management
  • Public-Private Partnerships
  • Health Economics

Background:

  • The UK Coalition Government seeks greater 'value' from operational healthcare Private Finance Initiative (PFI) projects.
  • NHS Trusts are under pressure to improve financial efficiency within existing PFI agreements.
  • Existing PFI contracts represent significant long-term financial commitments for the NHS.

Purpose of the Study:

  • To provide NHS Trusts with a framework for conducting contract savings reviews.
  • To identify key considerations for maximizing value within operational healthcare PFI contracts.
  • To support trusts in achieving greater financial efficiency from PFI investments.

Main Methods:

  • Analysis of key elements within operational PFI contracts.

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  • Review of best practices for contract savings initiatives in the healthcare sector.
  • Consultation with experts in built asset consultancy and health sector PFI management.
  • Main Results:

    • Identification of critical factors for successful contract savings reviews.
    • Development of a structured approach for NHS Trusts to assess PFI contract value.
    • Highlighting areas where 'value' can be enhanced within existing PFI agreements.

    Conclusions:

    • NHS Trusts must proactively undertake contract savings reviews to optimize PFI project value.
    • Strategic consideration of key contractual elements is essential for financial efficiency.
    • Effective management of PFI contracts is crucial for sustainable healthcare delivery.