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Updated: May 21, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

[The safety of macrolide antibiotics: critical analysis]

A I Sinopal'nikov, I V Andreeva, O U Stetsiuk

    Klinicheskaia Meditsina
    |June 14, 2012
    PubMed

    Insights

    Macrolide antibiotics are a safe and well-tolerated antimicrobial drug class. Their minimal adverse effects and reversible side effects make them suitable for diverse patient populations and infections.

    Area of Science:

    • Pharmacology
    • Infectious Diseases

    Context:

    • Macrolide antibiotics represent a crucial class of antimicrobial agents.
    • Assessing the safety profile of macrolides is essential for clinical practice.

    Purpose:

    • To review the safety and tolerability of macrolide antibiotics.
    • To highlight the advantages of macrolides over other antibiotic classes.

    Summary:

    • Macrolides exhibit a favorable safety profile with minimal toxicity (hematologic, nephrologic, cerebrotoxic).
    • They are free from severe adverse effects like anaphylaxis and toxico-allergic syndromes.
    • Reported side effects are typically functional, reversible, and resolve post-therapy.

    Impact:

    • The safety of macrolides supports their use in broad patient groups, including children, pregnant women, and the elderly.
    • Their tolerability facilitates treatment for various infections in both inpatient and outpatient settings.
    • Macrolides offer a valuable therapeutic option with a low risk of serious adverse events.

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