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Updated: May 21, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
[Coronary artery bypass grafting in the elderly patients: anesthesia and postoperative period]
Insights
Advanced age is not a contraindication for coronary heart disease surgery. Elderly patients undergoing bypass grafting surgery experienced beneficial outcomes in the early postoperative period, similar to younger patients.
Area of Science:
- Cardiology
- Cardiac Surgery
- Geriatric Medicine
Context:
- Chronic coronary heart disease (CCHD) affects a growing elderly population.
- Surgical interventions like aortocoronary/mammarocoronary bypass grafting are common treatments.
- The impact of advanced age on surgical outcomes requires careful evaluation.
Purpose:
- To determine if advanced age is a precipitating factor in anesthesia and bypass grafting surgery for CCHD patients.
- To compare outcomes between elderly CCHD patients (66-75 years) and a younger control group (60-65 years).
Summary:
- A study compared 34 elderly CCHD patients with 38 younger controls undergoing bypass surgery.
- Elderly patients had higher angina/heart failure classes and lower myocardial reserve.
- Despite longer procedure times (aortic compression, cardiopulmonary bypass, inotropic support, ventilation), outcomes were favorable.
Impact:
- Surgical treatment for elderly CCHD patients demonstrates beneficial early postoperative outcomes.
- Advanced age alone is not a contraindication for bypass grafting in CCHD.
- This research supports the consideration of surgical intervention for older CCHD patients.
Abstract:
The objective of the present work was to clarify whether the advanced age of the patients with chronic coronary heart disease may be a precipitating factor with respect to anesthesia and aortocoronary/mammarocoronary bypass grafting surgery. The study group was comprised of 34 patients at the age from 66 to 75 years. The control group consisted of 38 patients aged between 60 and 65 years. The two groups were matched for a variety of characteristics. The overall intrahospital lethality rate was estimated at 1.39% (including one patient from the control group). The patients of the study group were characterized by higher functional classes of angina and cardiac failure in conjunction with lower myocardial contractile reserve. The duration of aortic compression, artificial blood circulation, inotropic support, and artificial lung ventilation was greater in the study group than in the control one even though the total duration of the hospital stay was similar. It is concluded that the surgical treatment of elderly patients presenting with chronic coronary heart disease has beneficial outcome in the early postoperative period; for this reason, the advanced age is not a contraindication for the surgical intervention on such patients.
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