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Updated: May 21, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
[Risk factors of heatstroke]
Hidetaka Onda1, Hiroyuki Yokota
1Department of Emergency and Critical Care Medicine, Nippon Medical School.
Abstract:
In recent years, there has been an increased tendency for heatstroke to occur. A rise in mean temperature and the occurrence of extreme high temperatures and fine weather are environmental factors of risk. The prevalence of heatstroke characteristically increases before the passing of the rainy season, and approximately three times more men than women are susceptible. The age-specific distribution of heatstroke is bimodal and peaks at 10-20 and 50-60 years of age. For effective heatstroke prevention, however, many factors such as work environment and everyday life environment must be taken into account.
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Conduction, accounting for approximately 3% of body heat loss at rest, is the process of exchanging heat between molecules of two materials in direct contact. This can result in both heat loss and gain. For instance, when the body is submerged in water, which conducts heat 20 times more effectively than air, it can either lose or gain significant heat.

