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Updated: May 21, 2026
08:22
A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
[Sequelae secondary to heat-related illness]
1Department of Emergency and Critical Care Medicine, Showa University School of Medicine.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|June 14, 2012
Summary
Neurological sequelae affect 2.2% of heatstroke patients. Rapid, aggressive cooling and intensive care are crucial to prevent these severe central nervous system complications in heatstroke survivors.
Area of Science:
- Emergency Medicine
- Neurology
- Environmental Health
Context:
- Heatstroke poses a significant risk for neurological sequelae.
- Previous studies have not fully elucidated the predictors and outcomes of these complications.
- Data from multiple surveillance studies (2006, 2008, 2010) by the Japanese Association for Acute Medicine (JAAM) were analyzed.
Purpose:
- To determine the incidence of neurological sequelae in heatstroke patients.
- To identify clinical factors associated with the development of central nervous system sequelae.
- To inform optimal treatment strategies for heatstroke.
Summary:
- Neurological sequelae occurred in 2.2% of heat-related illness patients.
- Severe disturbance of consciousness, higher body temperature, and low base excess (BE) values upon hospital arrival were associated with increased risk.
- Patients developing sequelae required longer cooling times to reach target temperatures.
Impact:
- Highlights the importance of prompt and aggressive cooling measures.
- Emphasizes the need for intensive care to mitigate neurological damage.
- Provides evidence for early identification of high-risk patients to prevent long-term neurological deficits.
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